Study on the Effect of Gentiana in the Treatment of Rheumatoid Arthritis based on IL-6
Keywords:
Rheumatoid arthritis, IL-6, Inflammatory response, Gentiana, Mechanism of actionAbstract
Rheumatoid arthritis (RA) is an autoimmune disease that affects multiple joints on both sides. Its characteristic is progressive symmetrical inflammation of the affected joints, leading to cartilage destruction and bone erosion. In recent years, the role of interleukin-6 (IL-6) in health and disease has received widespread attention, and the inflammatory pathways involved in IL-6 have also contributed to the occurrence and progression of rheumatoid arthritis (RA) to a certain extent. Gentiana has the effects of dispelling wind and dampness, clearing dampness and heat, relieving pain and dampness, and reducing deficiency heat. It is commonly used to treat diseases such as rheumatic pain, muscle and meridian constriction, bone steaming and tidal heat, and damp heat jaundice. Research has found that Gentiana can reduce bone destruction, anti-inflammatory and apoptotic effects by inhibiting the secretion of pro-inflammatory cytokine IL-6 and regulating the signaling pathways involved in IL-6, achieving the therapeutic goals of rheumatoid arthritis. This review first reviews the role of IL-6 cytokines in the occurrence and progression of RA, and summarizes the mechanism of IL-6 in the treatment of rheumatoid arthritis by Gentiana, in order to provide reference for clinical application.
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