Research Progress of Chinese Medicine Monomer and Compound in the Treatment of Psoriasis by Regulating NF-κB Signaling Pathway

Abstract

Psoriasis is an immune-mediated inflammatory skin disease influenced by both genetic and environmental factors, marked by its chronicity, recurrence, and treatment resistance. Its pathogenesis is highly complex, encompassing a variety of genes, cytokines, and signaling pathways. Advances in the study of biological signaling pathways have revealed the NF-κB signaling pathway's involvement in the inflammatory response, cell proliferation, and apoptosis in psoriasis, positioning it as a potential therapeutic target. In recent years, the modern research and innovation of traditional Chinese medicine have advanced, showcasing significant therapeutic efficacy due to its multi-pathway, multi-target, and multi-component nature. A review of international literature reveals that traditional Chinese medicine monomers, active ingredients, and formulations can modulate the NF-κB signaling pathway, thereby reducing inflammatory responses, suppressing cell proliferation, modulating immunity, and managing oxidative stress to treat psoriasis. This article thus summarizes recent advancements in the use of traditional Chinese medicine monomers and compounds to modulate the NF-κB signaling pathway in the treatment of psoriasis, offering insights into the potential mechanisms of traditional Chinese medicine in this field.