Mechanism of Action and Clinical Application of Brain-gut Peptides in Intestinal Diseases

Abstract

Brain-gut peptides are secreted by gastrointestinal endocrine cells and neurons, which are involved in the regulation of gastrointestinal function, energy balance, immune response, and behavior, playing a crucial role in the "brain-gut axis." In recent years, it has been found that the expression of brain-gut peptides in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), as well as their regulatory mechanisms, are closely related to the occurrence and development of these diseases. Specifically, brain-gut peptides play a key role in these conditions by regulating intestinal motility, intestinal barrier function, and immune response. Additionally, relevant studies have identified brain-gut peptides as potential non-invasive diagnostic markers and therapeutic targets in the diagnosis and treatment of intestinal tumors. In this paper, we summarize the research progress on the mechanisms of brain-gut peptides in intestinal diseases and their clinical applications, with the aim of providing theoretical support for the development of new diagnostic and therapeutic methods.